Uthando Nethemba

Category: Evidence Notes

  • In clinical trials what is adequate power and how can we assume it?

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    In a clinical trial, adequate power refers to the probability that a trial will be able to detect a significant difference between the treatment and control groups if such a difference exists. The power of a trial is determined by several factors, including the sample size, the magnitude of the treatment effect, the variability of…

  • ICH E6

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    ICH E6 (R2) is a set of guidelines developed by the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) for the conduct of clinical trials. The guidelines were updated in November 2016 and are commonly referred to as ICH E6 (R2). The guidelines provide recommendations for the design, conduct, and…

  • what is pharmacodynamics and pharmacophysiology?

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    Pharmacodynamics and pharmacokinetics are two important concepts in pharmacology that describe the effects and actions of drugs in the body. Pharmacodynamics refers to the study of the biological and physiological effects of drugs, and how they interact with the body to produce their therapeutic or toxic effects. This includes the mechanisms of action of drugs,…