Category: Cardiometabolic

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Evidence-first notes on bioscience and deep tech, at the edge of the lab and the market. Information only — not investment advice, not medical advice. The 30-second version What. Lipoprotein(a) lowering is already a mature commercial field: three injectable siRNA/ASO agents are in large cardiovascular-outcome Phase 3 trials at roughly 90%+ Lp(a) reduction, an oral…

Oral muvalaplin and the measurement problem — why half of Lp(a)’s “efficacy gap” may be the ruler, not the drug

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Evidence-first notes on bioscience and deep tech, at the edge of the lab and the market. Information only — not investment advice, not medical advice. The 30-second version What. Muvalaplin (Eli Lilly, LY3473329) is the first oral, once-daily small molecule that lowers lipoprotein(a) — it blocks assembly of the Lp(a) particle rather than shutting off…

Lp(a) is causal — so how much do you have to lower it? Mendelian randomization, epidemiology and the 2026 guideline turn

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Evidence-first notes on bioscience and deep tech, at the edge of the lab and the market. Information only — not investment advice, and not medical advice. The 30-second version What. The causal case for lipoprotein(a), Lp(a), as a driver of atherosclerotic cardiovascular disease is one of the strongest genetic cases in cardiology — Mendelian randomization…

The Lp(a) landscape — a genetically fixed axis of residual cardiovascular risk, and the first drugs that lower it 90%+ (while the outcome question stays open)

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Evidence-first notes on bioscience and deep tech, at the edge of the lab and the market. Information only — not investment advice, not medical advice. The 30-second version What. Lipoprotein(a), or Lp(a), is a largely genetically fixed particle that Mendelian randomization (MR) has established as a causal axis of residual cardiovascular risk — the part…

In-vivo gene editing of the lipid axis — PCSK9, ANGPTL3 and Lp(a), and what a “one-shot, lifelong” lowering does and does not yet prove

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Evidence-first notes on bioscience and deep tech, at the edge of the lab and the market. Information only — not investment advice, not medical advice. The 30-second version What. In-vivo gene editing is now reproducing, in a permanent, single-dose form, the “lipid biomarker lowering” that siRNA/ASO drugs already established. Two programs have reached peer review:…

Making the molecule — the real rate-limiting step behind the GLP-1 headline is manufacturing physics, not efficacy

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Evidence-first notes on bioscience and deep tech, at the edge of the lab and the market. Information only — not investment advice, not medical advice. The 30-second version What. The headline for the GLP-1 class is efficacy (about −20% weight, about −20% cardiovascular events). But the real rate-limiting step for population-level access is manufacturing physics:…

Asia is not a full importer of the CKM/SMD naming war — it selectively adopts MASLD and keeps its own diagnostic thresholds

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Evidence-first notes on bioscience and medical affairs, at the edge of the clinic and the market. Information only — not investment advice, not medical advice. The 30-second version What. Korea and Asia have not officially imported the upper-level CKM/SMD taxonomy into society guidelines. The only nomenclature they have formally adopted is the MASLD renaming (Korean…

How far does definition-setting power reach? The four-layer chain from CKM taxonomy to guideline, ICD code and drug label

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Evidence-first notes on bioscience and medical affairs, at the edge of the clinic and the market. Information only — not investment advice, not medical advice. The 30-second version What. This part traces, layer by layer, how US definition-setting power moves down a four-stage chain — definition (taxonomy) → guideline (COR/LOE) → ICD code / reimbursement…

The drug is the battleground — what GLP-1, SGLT2i and resmetirom labels reveal about who really owns the CKM/SMD taxonomy

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