Tag: cardio-renal-metabolic
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Two Gates in Heart Failure: A Drug That Bound Its Target and Still Failed, and One That Passed Its Trial and Still Split on Reimbursement
Evidence-first notes on bioscience and deep tech, at the edge of the lab and the market. Information only — not investment advice, and not medical advice. This piece covers two separate, publicly documented events in the same disease area: a completed, peer-reviewed phase 2b trial (not a simulation, not a preprint) and two national health-technology-assessment…
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Blocking the Clot Is Not Protecting the Brain: An Unpeer-Reviewed UK Biobank Preprint on Atrial Fibrillation and Brain Health (n=502,099)
Correction, 2026-09-08. This piece originally stated that whether the authors adjusted for kidney function was unconfirmed, and that the plasma NfL finding could therefore not be separated from renal confounding. That was wrong, and the answer was in the preprint all along: its main text reports that results were unaltered by further adjustment for estimated…
