Tag: prime editing
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Mechanism-Encoded Prediction of Prime Editing: What OptiPrime’s Ablations Actually Prove, and What Remains Unconfirmed
Evidence-first notes on bioscience and deep tech, at the edge of the lab and the market. Information only — not investment advice. The Nature Biotechnology version of the paper discussed here is paywalled and was not accessed by this outlet. Everything below marked “confirmed” was verified directly against the bioRxiv preprint (submitted 2026-02-20), which the…
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Editing modality — nuclease, base, prime — and why the most precise editor is the least clinically mature
Evidence-first notes on bioscience and deep tech, at the edge of the lab and the market. Information only — not investment advice, not medical advice. The 30-second version What. In-vivo gene editing is not one technology but a precision spectrum: nuclease (double-strand break, random indels — a “knockout” tool) → base editing (single-base substitution, no…
