Tag: AlphaFold
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Protein foundation models (AlphaFold3, ESM3): does beating the specialist baseline mean generalization — or memorization?
Evidence-first notes on bioscience and deep tech, at the edge of the lab and the market. Information only — not investment advice. The 30-second version What. On FoldBench, a leakage-controlled independent benchmark, AlphaFold3 (AF3) leads on most tasks — but its score splits sharply by axis. It is robust on protein monomers (LDDT 0.88) and…
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Structure prediction, dissected — single-domain static folds are essentially solved (AlphaFold2, AlphaFold3 co-folding, ESMFold, the 2024 Nobel), but disorder, dynamics, PPI, ligand pose and mutation ΔΔG are the real frontiers
Evidence-first notes on bioscience and deep tech, at the edge of the lab and the market. Information only — not investment advice, not medical advice. All accuracy figures (CASP GDT, pLDDT, pTM, PoseBusters) are attributed to the primary paper or its sponsor; peer-reviewed results are separated inline from preprints and company blogs. Benchmark accuracy is…
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The AI protein-design landscape — structure prediction is near-solved at the headline, but generative de novo design’s real bottleneck is the in-silico-metric-to-wet-lab-function gap
Evidence-first notes on bioscience and deep tech, at the edge of the lab and the market. Information only — not investment advice, not medical advice. All success-rate, hit-rate and efficiency figures are attributed to the reporting paper or company; some are company blogs or preprints rather than peer-reviewed data (noted inline). In-silico design metrics (pLDDT,…
Uthando Nethemba 