Tag: structural biology
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Is Retrieval All You Need? Depends How You Score It — An In Silico Preprint Recalibrates Protein-Generator Novelty Claims
Evidence-first notes on bioscience and deep tech, at the edge of the lab and the market. Information only — not investment advice. The paper discussed here is an unpeer-reviewed arXiv preprint (submitted 2026-08-11), and every comparison in it — including the one summarized below — is an in silico structural alignment and scoring exercise. No…
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Structure prediction, dissected — single-domain static folds are essentially solved (AlphaFold2, AlphaFold3 co-folding, ESMFold, the 2024 Nobel), but disorder, dynamics, PPI, ligand pose and mutation ΔΔG are the real frontiers
Evidence-first notes on bioscience and deep tech, at the edge of the lab and the market. Information only — not investment advice, not medical advice. All accuracy figures (CASP GDT, pLDDT, pTM, PoseBusters) are attributed to the primary paper or its sponsor; peer-reviewed results are separated inline from preprints and company blogs. Benchmark accuracy is…
